Research interests

Currently, my research interests cover the areas of:

- physiologically-based pharmacokinetic/pharmacodynamic  (PBPK/PD) modeling

- drug combination therapies

- drug-drug interactions (DDI’s)

in cancer research.

Pharmacokinetics (PK) refer to what the body does to the drug whereas Pharmacodynamics  (PD) what the drug does to the body.  PBPK models have become increasingly widespread over the last decade in drug discovery of new compounds as well as in preclinical and clinical development (e.g. pediatric trials).

A full PBPK/PD model is taking into account the physiology of an individual or a population and links dose-concentration (PK) and concentration-effect (PD) relationships thereby facilitating the description and prediction of the time-course of the drug effects resulting from a certain dose regimen.  In the context of cancer, I am interested in predicting the optimal drug doses and routes of administration for chemotherapeutic agents and study their effect not only in terms of physiology (tumour shrinkage) but also at the molecular level (downstream signaling pathways).

Moreover, development of PBPK models can help dealing with complex DDI’s and predict patients’ response to drug combination therapies.

Finally, among my interests is writing and developing software tools/packages to facilitate research in the Computational Biomedicine field.

Education

2014-2015 Internship at European Bioinformatics Institute (EMBL-EBI), Systems Biomedicine Group
2013 Internship at INRIA Sophia-Antipolis, Structural Bioinformatics
2011-2014 MSc in Bioinformatics, National and Kapodistrian University of Athens
2005-2011 5-year Diploma in Computer Engineering and Informatics, University of Patras

Angeliki Kalamara

After obtaining my Diploma in Computer Engineering from the Polytechnic School at University of Patras I continued my Master studies with specialization in Bioinformatics at National and Kapodistrian University. During the last year of my master’s degree I spent half of my research term at INRIA Sophia-­Antipolis, as an intern in the Algorithms Biology Structure (ABS) team where I dealt with Cryo­–Electron Microscopy maps segmentation to detect the individual protein complex's subunits by heavily relying on computational geometry methods.

After that, I joined Dr. Julio Saez­-Rodriguez’s group at at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) as an intern where my main project was the analysis of microarray gene expression profiles of primary tumours and cell lines from colorectal cancer using consensus-based unsupervised clustering and association to drug response.

Currently, I conduct my doctoral thesis at Dr. Julio Saez-Rodriguez’s group at the Joint Research Center for Computational Biomedicine in Aachen where I am working on the development of physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) models.