Research interests

My research group is focused on interdisciplinary approaches combining systems biology, clinical research, and integrative data analysis towards testable hypotheses of clinical relevance and disease models with translational potential. A core interest is on protein homeostasis, or proteostasis, and a systems-level understanding of proteostasis network (PN) regulation throughout the human diseasome. The proteostasis network (PN) is an intricately regulated network uniting core processes that evolved to control proteome balance. Stressors and molecular alterations can compromise cellular proteostasis capacity, leading to disease. Understanding and modelling PN signaling at a systems level will help to rationalise therapeutic strategies to re-adjust proteostasis. A particular emphasis is on the chaperome, the ensemble of molecular chaperones and co-chaperones that evolved to safeguard native protein folding and function (Brehme, Cell Reports 2014). Other current activities also relate to predictive disease modeling and large-scale pharmacogenomics in cancers.

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Professional Career

2015 - 2017 Group Leader, Joint Research Center for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Aachen, Germany
2013 - 2015 Scientific Assistant to the Director, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
2013 Research Fellow, Northwestern University, Evanston, USA
2009 - 2012 Systems Biologist, Proteostasis Therapeutics Inc, Cambridge, USA
2009 - 2012 Research Fellow, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, USA
2009 - 2012 Research Fellow, Department of Genetics, Harvard Medical School, Boston, USA

Current scientific activities

2017 - present Editorial Board Member, Biology (MDPI)
2016 - present Member of COST Action PROTEOSTASIS BM1307
2015 - 2017 Co-host, JRC-COMBINE Systems Biomedicine Seminar Series


2009 Ph.D. in Molecular Biology, University of Vienna, Austria
2005 - 2009 Ph.D. student with Prof. Giulio Superti-Furga, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
2003 - 2005 M.Sc. in Molecular and Cellular Biology, University of Heidelberg, German Cancer Research Center (DKFZ), European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
2002 - 2003 Erasmus Student, School of Biological Sciences, University of Manchester, UK
2000 - 2002 Undergraduate Studies in Biology, University of Heidelberg, Germany

Marc Brehme

Profilbild Marc Brehme

Marc Brehme is a Research Group Leader in Disease Modeling at the Joint Research Center for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University.  LinkedIn

Selected Publications