In light of the fundamental role of the PN in maintaining cellular health, various questions arise with respect to cancer: • To what extent does the PN control cellular resilience to carcinogenesis and how is it altered in different cancers? • Which nodes and functional arms in the PN are crucially involved in tumorigenesis? • Are certain PN state changes associated with drug response, disease progression and outcome?
Modelling PN shifts during MPN progression will improve our understanding of the relationship between proteostasis signaling and carcinogenic transformation, towards improved predictive models of disease progression of clinical value for prognosis and patient risk assessment (Brehme et al. 2016).